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KMID : 0869619960130010054
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Journal of Korean Society of Hospital Pharmacists
1996 Volume.13 No. 1 p.54 ~ p.57
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Stability of Carbamazepine Syrup(Tegretol^(TM))
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박효정/Park, Hyo Jung
최혜진/김명민/최경업/Choi, Hye Jin/KIm, Myoung Min/Choi, Kyung Eob
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Abstract
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The stability of carbamazepine in 2% w/v syrup (Tegretol^(TM)) was investigated. Six Tegretol^(TM) syrup samples (Lot number:9083501) were selected randomly. The samples were then divided into 2 groups and stored as follows; Group I was stored at ambient room temperature and Group Ⅱ at 4℃ during 12 weeks. Physical stability was assessed by visual inspection and pH observation at designated time intervals (t=0, 1, 2, 3, 4, 8 and 12 weeks). Carbamazepine concentrations were determined periodically over 12 weeks by the fluorescence polarization immunoassay.
No significant changes in appearance, pH and drug concentrations of Tegretol™ syrups were observed under the two different temperature conditions over the duration studied.
In conclusion, pharmacists can safely dispense this preparation without considering the special storage conditions format least 12 weeks.
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